Razionale
From Mechanisms to Management: Pathophysiology and Therapy of Gastrointestinal, Hepatic and Pancreatic Diseases
The SIGE 2026 Course for Young Investigators aims to provide a high-level educational and scientific experience for early-career gastroenterologists, promoting a modern approach to digestive diseases grounded in pathophysiology, translational research, and personalized care.
The course is structured around the concept that understanding molecular and cellular mechanisms is essential to improve clinical reasoning, refine therapeutic choices, and develop innovative strategies for patient management. Key topics span gastrointestinal, hepatic, and pancreatic diseases, with a focus on emerging paradigms such as precision medicine, microbiota-driven interventions, and the integration of nutrition into clinical decision-making.
The educational model emphasizes active learning through interactive lectures, clinical challenges, and group-based discussions, fostering critical thinking and encouraging young investigators to engage in scientific debate and collaborative project development. A central objective is to strengthen the SIGE Young Investigator community by facilitating networking, mentorship, and shared research perspectives.
The collaboration with AISP further enriches the program, reinforcing the pancreatic track and enhancing the multidisciplinary and translational identity of the course.
Programma delle giornate
PRIMA SESSIONE
SECONDA SESSIONE
TERZA SESSIONE
QUARTA SESSIONE
QUINTA SESSIONE
SESTA SESSIONE
FUNDAMENTALS & EMERGING CONCEPT
Diet as a driver of chronic inflammation: from the gut to systemic disease
The gut-keeper: barrier integrity as a determinant of systemic health and disease
Gut-Liver axis: gut mucosal microbiota profiles in chronic liver disease
Core molecular pathways in pancreatic disease
UPPER GI
New concepts in GERD pathogenesis and treatment
Epidemiology, management and therapeutic innovation in eosiniphilic esophagitis
Functional dyspepsia from mechanisms to treatments
Role of microbiota and therapeutic potential of probiotics in dyspepsia
Dietary modulation of Upper-GI symptoms
Discussione interattiva Senior SIGE -Young - Clinical challenge
LOWER GI
IBS subtypes: from basic science to targeted therapy
Constipation and diarrhea: mechanism-based diagnosis and targeted therapy
Definition, natural history, and treatment of Eosinophilic Gastrointestinal Diseases: toward an immune-centric redefinition of emerging GI Inflammatory Disorder
Molecular mechanisms of inflammation in IBD: clinical targets for precision therapy
Dietary and pharmacological strategies in IBD-related intestinal failure
Discussione interattiva Senior SIGE-Young - Clinical challenge
LIVER and BILIARY
Precision portal hypertension: non-Invasive assessment and prevention of first decompensation
Bile acid signaling in liver disease: PPAR-agonists and emerging targeted therapies
Biomarkers and non-invasive assessment in the diagnosis and staging of MASLD
Primary sclerosing cholangitis: risk stratification and advanced diagnostic approaches — from MRCP to ERCP and cholangioscopy
Cirrhosis decompensation: biomarkers, endotypes, and emerging therapeutic targets
Discussione interattiva Senior SIGE -Young- Clinical challenge
PANCREAS (a cura di AISP)
Pancreatitis associated to gene mutations
Paraduodenal Pancreatitis
Autoimmune pancreatitis
Role of EUS in the evaluation of patients with chronic pancreatitis
Endoscopic therapeutic approach of patients with chronic pancreatitis
Discussione interattiva Senior SIGE -Young- Clinical challenge
FUTURE AGENDA
GLP-1/GIP agonists, mechanisms of action and GI side effects
Microbiome-based interventions: pre-, pro- and postbiotics
Multi-Omics revolution in digestive diseases: redefining diagnosis and therapeutic targets
Chrononutrition and precision nutrition for personalized dietary interventions
Discussione interattiva Senior SIGE -Young- Clinical challenge

